Klinfelters+Syndrome+(Sick+Genes)

Klinefelter Syndrome

**__ What is Klinefelter Syndrome? __**

** This is a disorder that affects only males. Males normally have an extra X chromosome and a Y chromosome (XY). But males who have Klinefelter syndrome have an extra X chromosome (XXY) giving them 47 instead of the normal 46 chromosomes. **

**__ Type of Genetic Mutation __**

Klinefelter syndrome results from the presence of a single extra copy of the X chromosome in each of a male's cells (47,XXY).

** What causes Klinefelter’s syndrome? ** Klinefelter’s Syndrome is caused by the presence of an additional X chromosome. This error usually occurs when the chromosomes are distributed during the division of the egg or the sperm. In more than half of the cases, the extra X chromosome is contributed by the father. Very little is known about the role of the mother’s age in bringing about this condition

**__ Epidemiology (United Sates) __** · Approximately 1 in 500-1,000 males is born with an extra sex chromosome; more than 3,000 affected males are born yearly. · The prevalence rate is 5-20 times higher in individuals with mental retardation than in the general newborn population. Approximately 250,000 men in the United States have Klinefelter syndrome.[7] Klinefelter syndrome does not have any racial predilection. Because the syndrome is caused by an additional X chromosome on an XY background, this condition affects only males.
 * Race **
 * Sex **

**__ What are the symptoms of Klinefelter syndrome? __** Many people with this disorder have no idea they have it until they hit puberty or they try to have children. At puberty, men with this syndrome often develop more breast tissue than normal. Men also have little to no facial hair and body hair. Some men with K S have a learning disability and at times may have an severe intellectual disability as well. About 25% of men with K S also have language delays.Also, boys with this syndrome may have a learning disability and difficulty and language development.

Can Klinefelter Syndrome be inherited?

==Klinefelter’s Syndrome is not inherited; it usually occurs as a random event during the formation of reproductive cells. It is believed that the extra X chromosome is given by the father. This is a random unexplained occurrence. ==

Images of males with Klinefelter's syndrome.

Diagnosis Klinefelter syndrome is most often diagnosed in adulthood using a karyotype, an analysis of the patient's chromosomes taken from a blood sample. Klinefelter syndrome may also be diagnosed during a woman's pregnancy. Doctors can look for the chromosome abnormality in cells taken from the amniotic fluid that surrounds the fetus (amniocentesis), or from the placenta (chorionic villus sampling (CVS). Prognosis

As babies, many XXY males have reduced muscle development and strength. Most, XXY males tend to be taller and may have less muscle control and coordination than other boys their age. During puberty, they do not make as much testosterone as other boys. This can lead to a taller, less muscular body, less facial and body hair, and broader hips than other boys. As teenagers, XXY males may have larger breasts, weaker bones, and a lower energy level than other boys. As adults XXY males are more likely than other men to have certain health problems, such as autoimune disorders,breast cancer,vein diseases osteoperosis and tooth decay and infertility. ** Treatment **

There is no known treatment for Klinefelter’s Syndrome since it’s a chromosomal abnormality.

** Interesting facts about Klinefelter syndrome **
 * 1) Klinefelter syndrome is one of the most common genetic abnormalities. It affects between 1 in 500 males.
 * 2) The disorder is named for Dr. Harry Klinefelter, who first reported its symptoms in 1942.