McLeod+Syndrome

Causes:
==McLeod syndrome is an X-Linked recessive mutation of the Kell blood group. The gene for McLeod Syndrome affects the XK gene which is on the X chromosome. The XK gene is what creates different proteins for the heart, brain and muscles. The protein is also present in red blood cells. If the XK gene is mutated it will produce very little to none of the antigen KX in the red blood cells. The reason behind the cause of McLeod Syndrome due to the XK gene mutation is unknown.==

Diagnosis:
==Usually McLeod Syndrome is more visible in people in their 5th decade or later. It is also more common in males due to McLeod Syndrome being an X-Linked recessive mutation. A blood test will show spiky red blood cells instead of circular or sickle-shaped if you have sickle-cell anemia. Other symptoms of the syndrome include peripheral neuropathy, cardiomyopathy, and muscle tics along with dementia.== ==Peripheral Neuropathy is when myelin sheaths are damaged in neurons and the signals to and from the brain are disrupted. This can lead to different limbs becoming immobile due to the nerves not being able to receive and send signals in that limb. Even erectile dysfunction in males due to the nerves being damaged in a male's genitals. The loss of control in the peripheral nervous system also causes muscle tics in which the patient can't control certain movements.== ==Cardiomyopathy is practically the heart being damaged. Heart murmurs or, "Arrhythmia" are one of the common types of cardiomyopathy. Cardiomyopathy can lead to cardiac arrest and eventually death. Cardiomyopathy can be worsened by environmental causes such as alcohol abuse and stress in the patient's daily life.==