Chronic+myelogenous+leukemia

=__**Sick Genes Activity **__=

**Chronic myelogeous leukemia**


Causes :Chronic Myelogeous Leukemia also known as CML is a disorder that is basically a cancer of white cells. What it does is that it changes the speed of the growth of a myeloid cell in the bone marrow. It is pretty much a stem cell disorder.

The good part of it is that there is a cure. The cure is tyrosine kinase ihibitors. It has dramatically improved survival rates in the past decade.


 * Symptoms:**


 * Enlarged spleen
 * Joint pain
 * easy bruising
 * anemia
 * low-grade fever
 * etc.

Type of mutation :The chromosome that is most affected by the disorder is the Philadelphia chromosome.



Treatment :Doctors or scientists still have not found out what starts the disorder but they do know how it functions. First there would be abnormal chromosomal growth. Somehow chromosome 9 mixes up with chromosome 22. It shortens the chromosome 22 and enlarges the chromosome 9. The group that will have this disorder will have to do with the age group. The actual disorder starts at middle-aged and elderly. The amount of people who have this disorder is sort of rare. It would be 1-2 people out of 100,000 others that will get the disorder. CML is suspected on the base on the complete blood count. Also based on the maturity of the myeloid cells. " A follow-up on patients using imatinib published in the New England Journal of Medicine in 2006 showed an overall survival rate of 89% after five years."

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